At Insmed, every moment and every patient counts — and so does every person who joins in. As a global biopharmaceutical company dedicated to transforming the lives of patients with serious and rare diseases, you’ll be part of a community that prioritizes the human experience, celebrates curiosity, and values every person’s contributions to meaningful progress. That commitment has earned us recognition as Science magazine’s No. 1 Top Employer for five consecutive years, certification as a Great Place to Work® in the U.S., and a place on The Sunday Times Best Places to Work list in the UK.
For patients, for each other, and for the future of science, we’re in. Are you?
About the Role
Insmed is building its Drug Metabolism and Pharmacokinetics (DMPK) capabilities in Cambridge, UK, to help accelerate the progression of our growing pipeline of small molecule and antisense oligonucleotide (ASO) therapeutics, and we're seeking a dynamic and experienced Associate Director DMPK to help lead this exciting endeavor.As a Discovery DMPK Project Lead, you will represent DMPK on multidisciplinary drug discovery teams, leveraging your deep expertise in ADME and PKPD science to drive projects to successful development candidate nomination, and will form a vital bridge between our early Discovery and preclinical development teams. Collaborating closely with chemistry and biology colleagues, you will also benefit from access to our growing informatics platform, being built to deliver world-class modelling and simulation tools to accelerate learning and maximize probability-of-success for candidate delivery.
This is a unique opportunity to help establish and shape DMPK as a key Discovery discipline within a newly formed team.
You will have the opportunity to help grow our UK DMPK strategy, influence project direction and key decision-making, strengthen collaborations with our US DMPK team and external CRO vendors, and help build a high-performing DMPK function within an ambitious and rapidly growing organization.
What You'll Do
- Collaboratively develop and refine our UK Discovery ADME and PKPD strategies.
- Design and interpret nonclinical ADME studies to guide molecule design and optimization, to predict likely human drug disposition, and to support molecule progression to nonclinical toxicology studies.
- Work closely with chemistry to identify, contextualize and mitigate molecule development risks, using data from ADME, nonclinical safety and drug-drug interaction (DDI) experiments.
- Work closely with biology to build confidence in therapeutic drug exposure, using data from in vitro and in vivo pharmacology studies.
- Work closely with informatics to apply the power of modelling & simulation (ADMET, QSAR, PK, PKPD, PBPK) to integrate these data to deliver confident human PK and dose projections, and drive informed decisions on candidate selection, safety margins and dose optimization.
- Play a pivotal tactical and strategic role within Discovery project teams, providing critical data, context and insight to help guide project decision-making.
- Forge strong relationships with external Contract Research Organizations (CROs) to ensure rapid access to quality DMPK data.
- Partner closely with multidisciplinary teams across our UK Discovery projects and US sites.
Who You Are
- PhD in Pharmacokinetics, Pharmacology, Biochemistry, Pharmaceutical Sciences, or a related field.
- A minimum of 8 years of DMPK experience within the biotech/pharmaceutical industry, ideally within smaller, multifaceted organizations.
- A consistent record of meaningful contributions as a DMPK representative within cross-functional Discovery project teams, resulting in the successful nomination of clinical development candidates.
- Deep expertise and extensive experience in designing, commissioning and interpreting nonclinical ADME, safety and DDI studies, and performing human PK and dose predictions.
- Proven success in managing interactions with Contract Research Organizations (CROs) and encouraging effective cross-functional collaborations.
- Outstanding communication, critical thinking, and problem-solving competence.
- This role will require you to work from our brand-new state-of-the-art offices and labs situated in Babraham Research Campus, South Cambridge. Hybrid working is offered based on specific business needs and the role requirements.
Desirable:
- Experience working with antisense oligonucleotide (ASO) therapeutics, and compounds targeting the central nervous system (CNS).
- Hands-on experience with PK, PKPD and/or PBPK modelling (Phoenix WinNonlin, Simcyp, GastroPlus, etc) or ADMET prediction software.
Life At Insmed
Our research site in Cambridge, UK is situated in brand new labs and offices at the Babraham Research Campus—a leading hub for bioscience innovation and collaboration. Our team of biologists, human geneticists, bioinformaticians, data scientists, computational and synthetic chemists bring together a wide range of technologies and modalities to deliver powerful new ways of treating serious diseases.
At Insmed, you’ll find a culture as human as our mission—intentionally designed for the people behind it. You deserve a workplace that reflects the same care you bring to your work each day, with support for how you work, how you grow, and how you show up for patients, your team, and yourself.
Our offerings include:
- Flexible work schedules with purposeful in-person collaboration
- Competitive retirement benefits, global equity awards, and participation in our Employee Stock Purchase Plan (ESPP)
- Career development through the Insmed Learning Institute, external programs, LinkedIn Learning, and role-specific training
- AI-powered and on-demand learning tools, including a digital assistant to help navigate internal resources
- Hybrid-friendly technology and IT support for seamless teamwork across locations and time zones
- Global recognition programs and Employee Resource Groups
- Eligibility for specific programs may vary and is subject to the terms and conditions of each plan
Eligibility for specific programs may vary and is subject to the terms and conditions of each plan.
Current Insmed Employees: Please apply via the Jobs Hub in Workday.
Insmed Incorporated is an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, age, or any other characteristic protected by law.
Unsolicited resumes from agencies should not be forwarded to Insmed. Insmed will not be responsible for any fees arising from the use of resumes through this source. Insmed will only pay a fee to agencies if a formal agreement between Insmed and the agency has been established. The Human Resources department is responsible for all recruitment activities; please contact us directly to be considered for a formal agreement.
Insmed is committed to providing access, equal opportunity, and reasonable accommodation for individuals with disabilities in employment, its services, programs, and activities. To request reasonable accommodation to participate in the job application or interview process, please contact us by email at TotalRewards@insmed.com and let us know the nature of your request and your contact information. Requests for accommodation will be considered on a case-by-case basis. Please note that only inquiries concerning a request for reasonable accommodation will be responded to from this email address.
Applications are accepted for 5 calendar days from the date posted or until the position is filled.
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